A comprehensive study published in The Lancet has revealed that sleep patterns significantly impact cardiovascular health more than previously understood, with irregular sleep schedules posing similar risks to smoking and obesity.
The research, which tracked 103,000 participants over seven years, found that individuals with irregular sleep patternsโeven when getting adequate total sleep hoursโshowed a 26% higher risk of cardiovascular events including heart attack and stroke compared to those with consistent sleep-wake schedules.
The Circadian Connection
“What we’re seeing is that it’s not just about how much sleep you get, but also when you get it,” explains Dr. Michael Thornton, a cardiologist at Johns Hopkins University who was not involved in the study. “The body’s circadian rhythm affects everything from blood pressure regulation to inflammation levels.”

The study used wearable devices to track participants’ actual sleep patterns rather than relying on self-reported data. Researchers measured “sleep regularity index” scores, which reflect how consistent a person’s sleep-wake timing is from day to day. Those with the most irregular patterns showed elevated levels of inflammatory markers and higher cortisol levelsโboth risk factors for cardiovascular disease.
Particularly concerning was the finding that weekend “catch-up sleep” doesn’t mitigate these risks. Participants who maintained regular schedules during weekdays but dramatically shifted their sleep times on weekends showed nearly identical cardiovascular risks to those with consistently irregular patterns.
Practical Implications
The research has important implications for shift workers, who comprise approximately 20% of the workforce in developed countries. Study data showed that rotating shift workers had the highest cardiovascular risk, suggesting that occupational sleep disruption may be a significant public health concern.
However, the study also offered encouraging news: participants who improved their sleep regularity over time showed measurable reductions in cardiovascular risk markers within six months. Even modest improvementsโgoing to bed and waking up within a one-hour window most daysโyielded health benefits.
Dr. Elena Rodriguez, lead author of the study, recommends that healthcare providers begin screening patients for sleep irregularity as routinely as they check blood pressure. “This is a modifiable risk factor that we can address with relatively simple behavioral interventions,” she notes.
The American Heart Association is expected to incorporate sleep regularity into its cardiovascular health metrics, joining factors like diet, exercise, and smoking status as key determinants of heart health.
